Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666599 | 0.94 | CHRNB2 (0.43) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL16405081 | 0.94 | CHRNB2 (0.43) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL634724 | 0.94 | CHRNB2 (0.43) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL28603590 | 0.93 | CHRNB2 (0.42) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL15169508 | 0.93 | CHRNB2 (0.42) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL27828833 | 0.93 | CHRNB2 (0.42) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Naphthalene SCHEMBL27966102 | 0.85 | ADRA1A (0.45) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL27758904 | 0.84 | CREBBP (0.38) | CHRNB2CHRNA4CHRNA7ADRA1AADRA1D | |
| SCHEMBL27651097 | 0.74 | ADRA1A (0.40) | SMN1; SMN2ADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL184451 | 0.74 | ADRA1A (0.55) | SMN1; SMN2ADRA1AADRA1DADRA1BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | claimed |
| EP-0397614-A2 | Pharmacologically active piperdinylimidazopyridines | DOMPE' FARMACEUTICI S.p.A. (IT) | 1990-11-14 | — | — | EP | claimed |
| CN-109851610-B | Bicyclic aza compounds as muscarinic M1 and/or M4 receptor agonists | 赫普泰雅治疗有限公司 | 2021-09-21 | — | — | CN | disclosed |
| EP-1349850-B1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOD CONSEILS RECH APPLIC (FR) | 2005-09-07 | — | — | EP | disclosed |
| EP-1349850-B1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOD CONSEILS RECH APPLIC (FR) | 2005-09-07 | — | — | EP | disclosed |
| CN-1214025-C | Sodium channel modulators derived from 2-piperidylimidazoles | SOD CONSEILS RECH APPLIC (FR) | 2005-08-10 | — | — | CN | disclosed |
| CN-1214025-C | Sodium channel modulators derived from 2-piperidylimidazoles | SOD CONSEILS RECH APPLIC (FR) | 2005-08-10 | — | — | CN | disclosed |
| CN-1214025-C | Sodium channel modulators derived from 2-piperidylimidazoles | SOD CONSEILS RECH APPLIC (FR) | 2005-08-10 | — | — | CN | disclosed |
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-22 | — | — | US | disclosed |
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-22 | — | — | US | disclosed |
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-22 | — | — | US | disclosed |
| CN-1483029-A | Sodium channel modulators derived from 2-piperidylimidazoles | ��ѧ�о���Ӧ����ѯ��˾ | 2004-03-17 | — | — | CN | disclosed |
| CN-1483029-A | Sodium channel modulators derived from 2-piperidylimidazoles | ��ѧ�о���Ӧ����ѯ��˾ | 2004-03-17 | — | — | CN | disclosed |
| CN-1483029-A | Sodium channel modulators derived from 2-piperidylimidazoles | ��ѧ�о���Ӧ����ѯ��˾ | 2004-03-17 | — | — | CN | disclosed |
| EP-1349850-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-10-08 | — | — | EP | disclosed |
| EP-1349850-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002053559-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053559-A1 | SODIUM CHANNEL MODULATORS DERIVED FROM 2-PIPERIDYLIMIDAZOLES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077640-A1 | Sodium channel modulators derived from 2-piperidylimidazoles | KCNH1, HCN4, KCNH2 | CHRNB2 342/4885CHRNA4 125/4885MEN1 4835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.