Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408954 | 0.86 | MAPT (0.53) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9196087 | 0.81 | MTNR1A (0.42) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6174415 | 0.77 | CYP2C9 (0.58) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6174074 | 0.76 | SIGMAR1 (0.36) | ALDH1A1SMN1; SMN2NQO1CYP2C9HTR2B | |
| SCHEMBL6174518 | 0.76 | VKORC1 (0.55) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6175677 | 0.75 | PGAM1 (0.47) | MAPTMCL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6173543 | 0.74 | CYP2C9 (0.55) | ALDH1A1MEN1KMT2ANQO1CYP2C9 | |
| SCHEMBL6175609 | 0.73 | CYP2C9 (0.54) | ALDH1A1MEN1KMT2ANQO1CYP2C9 | |
| SCHEMBL6173602 | 0.73 | CYP2C9 (0.54) | ALDH1A1MEN1KMT2ANQO1CYP2C9 | |
| SCHEMBL6175124 | 0.73 | CYP2C9 (0.54) | ALDH1A1MEN1KMT2ANQO1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| CN-1040321-C | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses | UPJOHN CO (US) | 1998-10-21 | — | — | CN | disclosed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |
| CN-1090279-A | Be used for the treatment of HIV and other retroviral pyran-2-ones and 5,6-dihydropyrane-2-ketone | UPJOHN CO (US) | 1994-08-03 | — | — | CN | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |