Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173980 | 0.92 | CCR6 (0.42) | ABL1SCN9ACCR6LRRK2MCHR1 | |
| SCHEMBL6173346 | 0.85 | EPHX2 (0.40) | ABL1TRPV4LMNAGPR139MAPK7 | |
| SCHEMBL6173438 | 0.82 | LMNA (0.42) | ABL1MCHR1LMNAHRH4POLB | |
| SCHEMBL6175578 | 0.82 | LMNA (0.42) | MCHR1LMNAHRH4GPR139POLB | |
| SCHEMBL6176756 | 0.82 | LMNA (0.42) | MCHR1LMNAHRH4POLBL3MBTL1 | |
| SCHEMBL6175660 | 0.81 | LMNA (0.40) | MCHR1LMNAHRH4GPR139POLB | |
| SCHEMBL6172084 | 0.81 | LMNA (0.40) | MCHR1LMNAHRH4GPR139POLB | |
| SCHEMBL6177656 | 0.81 | LMNA (0.37) | ABL1TRPV4SCN9AMAP4K1LMNA | |
| SCHEMBL6177038 | 0.80 | LMNA (0.42) | MCHR1LMNAGPR139POLBL3MBTL1 | |
| SCHEMBL6171053 | 0.80 | LMNA (0.40) | MCHR1LMNAHRH4POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |