Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL5790927 | 0.86 | MEN1 (0.60) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL17828166 | 0.84 | ACHE (0.47) | KDM4EKMT2AALDH1A1HTTGAA | |
| SCHEMBL2495479 | 0.81 | KMT2A (0.44) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL17828051 | 0.79 | CHRNB4 (0.41) | KDM4EKMT2AALDH1A1HTTGAA | |
| SCHEMBL3161038 | 0.77 | MEN1 (0.82) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL27644587 | 0.76 | GAA (0.54) | KDM4EKMT2AALDH1A1GAAHRH3 | |
| SCHEMBL27643123 | 0.76 | GNAI3 (0.39) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL13284339 | 0.75 | MEN1 (0.79) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL24582721 | 0.73 | CACNA1B (0.50) | KDM4ETDP1ALDH1A1L3MBTL1CACNA1B | |
| SCHEMBL20476270 | 0.73 | CHRNB2 (0.50) | KDM4EMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875017-A | Naphthalene-1, 5-disulfonic acid salts of substituted 4-amino-1- (pyridylmethyl) piperidine compounds | THERAVANCE INC (US) | 2006-12-06 | — | — | CN | claimed |
| EP-1556372-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004041806-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2004-05-21 | — | — | WO | claimed |
| CN-100364990-C | Substituted 4-amino-1- (pyridylmethyl) piperidines and related compounds | THERAVANCE INC (US) | 2008-01-30 | — | — | CN | disclosed |
| CN-1875017-A | Naphthalene-1, 5-disulfonic acid salts of substituted 4-amino-1- (pyridylmethyl) piperidine compounds | THERAVANCE INC (US) | 2006-12-06 | — | — | CN | disclosed |
| CN-1708494-A | Substituted 4-amino-1- (pyridylmethyl) piperidines and related compounds | THERAVANCE INC (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1556372-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041806-A2 | SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2004-05-21 | — | — | WO | disclosed |