Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 9/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | GIPR | P48546 | 2/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175298 | 0.92 | GRM5 (0.45) | GCGRIGF1R | |
| SCHEMBL6177003 | 0.88 | TDP1 (0.42) | GAAGCGRITGALIGF1R | |
| SCHEMBL6175271 | 0.87 | IGF1R (0.53) | LMNAGAAIGF1R | |
| SCHEMBL6172182 | 0.86 | LMNA (0.44) | LMNAGAANPC1RAB9ACYP3A4 | |
| SCHEMBL6172735 | 0.85 | IGF1R (0.42) | GAACYP3A4CYP2C9CYP2C19IGF1R | |
| SCHEMBL6222480 | 0.85 | MAPT (0.46) | CYP2C9ITGALIGF1R | |
| SCHEMBL6177217 | 0.85 | TLR7 (0.39) | GAAGCGRNAMPTCYP3A4CYP2C9 | |
| SCHEMBL6173624 | 0.85 | IGF1R (0.42) | GAAGCGRNAMPTCYP3A4CYP2C9 | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | GAACYP3A4CYP2C9CYP2C19ITGAL | |
| SCHEMBL6173728 | 0.84 | MEN1 (0.47) | NAMPTNPC1RAB9AIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |