Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369010 | 0.80 | HSD17B10 (0.62) | TSHRSMN1; SMN2HSD17B10ALDH1A1LMNA | |
| SCHEMBL21476509 | 0.80 | CYP2A6 (0.60) | CYP2A6TSHRSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL28009614 | 0.78 | TSHR (0.51) | TSHRSMN1; SMN2HSD17B10MAPTALDH1A1 | |
| SCHEMBL6051840 | 0.78 | TSHR (0.69) | MAPK1TSHRSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL2203423 | 0.76 | MAPT (0.54) | MAPK1CYP2A6RAB9AMAPTALDH1A1 | |
| SCHEMBL2377563 | 0.76 | DAPK3 (0.56) | MAPK1CYP2A6TSHRSMN1; SMN2RAB9A | |
| SCHEMBL3491216 | 0.76 | MAPK1 (0.52) | MAPK1CYP2A6KDM4EMAPTALDH1A1 | |
| SCHEMBL6609445 | 0.76 | ALDH1A1 (0.53) | MAPK1CYP2A6TSHRSMN1; SMN2KDM4E | |
| SCHEMBL14689223 | 0.75 | CYP2A6 (0.53) | MAPK1CYP2A6RAB9AMAPTL3MBTL1 | |
| SCHEMBL3237419 | 0.74 | ALDH1A1 (0.65) | MAPK1CYP2A6KDM4ERAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562908-A1 | QUINOLINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6894062-B1 | Quinoline derivatives | PFIZER INC. (US) | 2005-05-17 | — | — | US | disclosed |
| WO-2004043929-A1 | QUINOLINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-05-27 | — | — | WO | disclosed |