Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519206 | 0.82 | CYP11B2 (0.37) | CYP11B1CYP11B2CYP19A1ALDH1A1LMNA | |
| SCHEMBL5120274 | 0.75 | BRAF (0.37) | CYP11B1CYP11B2CYP19A1ALDH1A1LMNA | |
| SCHEMBL1856486 | 0.72 | HSD17B10 (0.53) | CYP11B1CYP11B2CYP1A2CASP1CASP7 | |
| SCHEMBL31137714 | 0.72 | CASP1 (0.53) | CYP11B1CYP11B2CYP1A2MKNK1CASP1 | |
| SCHEMBL20710609 | 0.70 | CYP3A4 (0.48) | CYP11B1CYP11B2CYP1A2HSD17B10CYP19A1 | |
| SCHEMBL1892118 | 0.70 | CYP3A4 (0.48) | CYP11B1CYP11B2CYP1A2HSD17B10CYP19A1 | |
| SCHEMBL8002224 | 0.66 | CASP1 (0.42) | CYP11B1CYP11B2CYP1A2CASP1CASP7 | |
| SCHEMBL4323285 | 0.65 | CYP1A2 (0.53) | CYP11B1CYP11B2CYP1A2MKNK1CASP1 | |
| SCHEMBL29792666 | 0.65 | CYP1A2 (0.53) | CYP11B1CYP11B2CYP1A2MKNK1CASP1 | |
| SCHEMBL389710 | 0.65 | MAOB (0.78) | CASP1CASP7HSD17B10HSD17B1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397354-B1 | IMIDAZOLE-2-CARBOXAMIDE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2005-10-26 | — | — | EP | disclosed |
| EP-1318992-B1 | IMIDAZOLE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2005-07-27 | — | — | EP | disclosed |