Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5827389 | 0.99 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2EPHX2TSHR | |
| SCHEMBL6174321 | 0.82 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2EPHX2TSHR | |
| Hydrochloric Acid SCHEMBL5827357 | 0.81 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2EPHX2TSHR | |
| SCHEMBL5828201 | 0.78 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2EPHX2TSHR | |
| SCHEMBL30543425 | 0.75 | ADRA2A (0.58) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29222702 | 0.75 | ADRA2A (0.58) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30543403 | 0.75 | ADRA2A (0.58) | — | |
| SCHEMBL29222936 | 0.75 | ADRA2A (0.58) | — | |
| SCHEMBL5827903 | 0.75 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2EPHX2TSHR | |
| SCHEMBL6172526 | 0.74 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2EPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |