Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174506 | 0.92 | CYP3A4 (0.43) | MAPTGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6171727 | 0.92 | HSD11B1 (0.36) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174812 | 0.91 | ALDH1A1 (0.38) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6172582 | 0.87 | ALDH1A1 (0.36) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174915 | 0.85 | MAPT (0.38) | MAPTGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6173429 | 0.84 | POLB (0.41) | MAPTGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6173440 | 0.83 | CYP3A4 (0.38) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175217 | 0.82 | GAA (0.42) | MAPTGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6173690 | 0.82 | CYP3A4 (0.41) | MAPTGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2941010 | 0.81 | CYP3A4 (0.36) | GAACYP3A4CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |