Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173352 | 0.92 | CYP3A4 (0.35) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6173842 | 0.90 | PRKDC (0.36) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6175872 | 0.85 | EPHX2 (0.40) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6173429 | 0.83 | POLB (0.41) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6173690 | 0.82 | CYP3A4 (0.41) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6171968 | 0.81 | CYP3A4 (0.36) | TRPV4MAP4K1CYP3A4ALDH1A1GAA | |
| SCHEMBL6173283 | 0.80 | CYP3A4 (0.38) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL2941010 | 0.80 | CYP3A4 (0.36) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6173440 | 0.80 | CYP3A4 (0.38) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 | |
| SCHEMBL6172522 | 0.80 | CYP3A4 (0.40) | CYP3A4ALDH1A1GAACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |