Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175204 | 0.87 | IGF1R (0.38) | TP53MDM2ALDH1A1HRH4 | |
| SCHEMBL6176027 | 0.86 | HRH4 (0.33) | TP53MDM2CYP3A4GAACYP2C9 | |
| SCHEMBL6172522 | 0.86 | CYP3A4 (0.40) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175486 | 0.85 | CYP3A4 (0.40) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174909 | 0.85 | TRPV4 (0.37) | ABL1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6174774 | 0.83 | SLC5A1 (0.40) | ABL1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173899 | 0.82 | ALDH1A1 (0.39) | TP53CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173429 | 0.81 | POLB (0.41) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174636 | 0.80 | ALDH1A1 (0.41) | ABL1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6175575 | 0.80 | EPHX2 (0.40) | EPHX2TP53MDM2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |