Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174909 | 0.81 | TRPV4 (0.37) | CYP3A4GAACYP2C9CYP2C19KCNH2 | |
| SCHEMBL6172495 | 0.78 | HTR2C (0.36) | CYP3A4CYP2C9KCNH2ABL1HTR2C | |
| SCHEMBL6172891 | 0.76 | CCR6 (0.34) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6177653 | 0.76 | TRPV4 (0.37) | CYP3A4GAACYP2C9CYP2C19KCNH2 | |
| SCHEMBL6174365 | 0.75 | HTR6 (0.35) | CYP3A4GAACYP2C9CYP2C19KCNH2 | |
| SCHEMBL6173352 | 0.73 | CYP3A4 (0.35) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6177656 | 0.72 | LMNA (0.37) | CYP3A4KCNH2ALDH1A1ABL1HTR2C | |
| SCHEMBL6173842 | 0.72 | PRKDC (0.36) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175872 | 0.71 | EPHX2 (0.40) | CYP3A4GAACYP2C9CYP2C19KCNH2 | |
| SCHEMBL6174088 | 0.71 | IGF1R (0.42) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |