Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30948751 | 0.80 | NR3C2 (0.47) | TRPV1 | |
| SCHEMBL6174576 | 0.80 | RAB9A (0.61) | NPC1RAB9AHTTATMMEN1 | |
| SCHEMBL20995614 | 0.79 | CA1 (0.47) | TRPV1NPC1RAB9ANTRK1 | |
| SCHEMBL23111950 | 0.78 | TRPV1 (0.51) | TRPV1NPC1RAB9ANTRK1 | |
| SCHEMBL29561782 | 0.78 | TRPV1 (0.51) | TRPV1NPC1RAB9ANTRK1 | |
| SCHEMBL30648563 | 0.78 | RAB9A (0.88) | NPC1RAB9AHTTATMMEN1 | |
| SCHEMBL17506268 | 0.77 | NPC1 (0.51) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL14439750 | 0.76 | NPC1 (0.61) | NPC1RAB9AKCNK3KCNK9HTT | |
| SCHEMBL3820618 | 0.76 | HTT (0.66) | NPC1RAB9AHTTATMMEN1 | |
| SCHEMBL23566394 | 0.76 | USP2 (0.68) | NPC1RAB9AKCNK3KCNK9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |
| EP-3362436-B1 | PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS | UNIV ANTWERPEN (BE) | 2021-06-30 | — | — | EP | disclosed |
| CN-102030771-B | Compound used as transient receptor potential vanilloid (TRPV1) blocker, medicinal composition and pharmaceutical application thereof | SUN QUN | 2013-07-17 | — | — | CN | disclosed |