Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175038 | 0.89 | LMNA (0.38) | IGF1RMAPK1LARS1LMNAKDM4E | |
| SCHEMBL6176514 | 0.86 | NAMPT (0.41) | IGF1RMAPK1NAMPT | |
| SCHEMBL6173894 | 0.85 | IGF1R (0.37) | IGF1RMAPK1LARS1LMNAHTT | |
| SCHEMBL6175530 | 0.84 | IGF1R (0.37) | IGF1RLMNAKDM4ETRPV3 | |
| SCHEMBL6172718 | 0.83 | IGF1R (0.36) | IGF1RLMNATRPV3 | |
| SCHEMBL6175730 | 0.82 | IGF1R (0.38) | IGF1RMAPK1LMNAKDM4EALDH1A1 | |
| SCHEMBL6173182 | 0.82 | IGF1R (0.40) | IGF1RLARS1LMNANPC1 | |
| SCHEMBL6174151 | 0.81 | NAMPT (0.35) | IGF1RLARS1LMNAELANENPC1 | |
| SCHEMBL6174217 | 0.81 | IGF1R (0.38) | IGF1RLMNAKDM4EALDH1A1NPC1 | |
| SCHEMBL6173893 | 0.80 | LMNA (0.39) | IGF1RMAPK1LMNAALDH1A1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |