Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175033 | 0.87 | MAPK1 (0.41) | NAMPTMAPK1 | |
| SCHEMBL6173973 | 0.87 | IGF1R (0.46) | MAPK1IGF1R | |
| SCHEMBL6175063 | 0.86 | IGF1R (0.38) | NAMPTMAPK1IGF1R | |
| SCHEMBL6173893 | 0.85 | LMNA (0.39) | MAPK1IGF1R | |
| SCHEMBL6175377 | 0.83 | IGF1R (0.35) | IGF1RMAPK14 | |
| SCHEMBL6174034 | 0.83 | CBLB (0.36) | IGF1R | |
| SCHEMBL6174217 | 0.82 | IGF1R (0.38) | IGF1R | |
| SCHEMBL6171910 | 0.82 | NAMPT (0.47) | NAMPT | |
| SCHEMBL6174110 | 0.82 | NPC1 (0.39) | IGF1RMAPK14 | |
| SCHEMBL6172184 | 0.82 | NPC1 (0.39) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |