Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173243 | 0.90 | METAP2 (0.37) | NAMPTIGF1RELANELMNARXFP1 | |
| SCHEMBL6172043 | 0.89 | IGF1R (0.37) | NAMPTIGF1RELANELMNA | |
| SCHEMBL6173101 | 0.89 | LMNA (0.38) | NAMPTELANELMNALARS1HTT | |
| SCHEMBL6174557 | 0.87 | IGF1R (0.33) | IGF1RLMNAPTGS1PTGS2 | |
| SCHEMBL6171910 | 0.86 | NAMPT (0.47) | NAMPTELANE | |
| SCHEMBL6174116 | 0.84 | IGF1R (0.33) | IGF1RLMNAPTGS1PTGS2 | |
| SCHEMBL6176687 | 0.83 | IGF1R (0.33) | IGF1RLMNA | |
| SCHEMBL6176021 | 0.83 | IGF1R (0.34) | IGF1RLMNAHTTRXFP1PTGS1 | |
| SCHEMBL6175063 | 0.81 | IGF1R (0.38) | NAMPTIGF1RELANELMNALARS1 | |
| SCHEMBL6175990 | 0.81 | KIF11 (0.37) | NAMPTIGF1RLMNALARS1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |