Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.32 |
| ▸ | ROS1 | P08922 | 3/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 2/20 | 0.31 |
| ▸ | LCAT | P04180 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173460 | 0.81 | HTR2A (0.34) | HTR2AHTR6MAPK7LIPE | |
| SCHEMBL6171937 | 0.74 | IGF1R (0.41) | — | |
| SCHEMBL6173312 | 0.69 | IGF1R (0.34) | HTR6 | |
| SCHEMBL2940231 | 0.69 | KMT2A (0.48) | TRPV4GPR139 | |
| SCHEMBL6172228 | 0.69 | IGF1R (0.35) | — | |
| SCHEMBL6173685 | 0.68 | HTR6 (0.33) | HTR2AHTR6TRPV4MAPK7LIPE | |
| SCHEMBL2941605 | 0.66 | GCGR (0.42) | — | |
| SCHEMBL2938270 | 0.66 | ACACB (0.37) | GPR139TP53 | |
| SCHEMBL6174365 | 0.65 | HTR6 (0.35) | HTR2AHTR6MAPK7LIPELCAT | |
| SCHEMBL6173992 | 0.65 | CCR6 (0.40) | SCN9AGPR139LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |