Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | TP53 | P04637 | 6/20 | 0.55 |
| ▸ | CETP | P11597 | 1/20 | 0.53 |
| ▸ | UTRN | P46939 | 4/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032178 | 0.82 | MAPT (0.60) | MAPTTP53UTRNHTR2BHSD17B10 | |
| SCHEMBL27652488 | 0.82 | HSD17B10 (0.70) | MAPTTP53CETPUTRNHTR2B | |
| SCHEMBL9112906 | 0.81 | HSD17B10 (0.54) | MAPTTP53CETPUTRNHTR2B | |
| SCHEMBL9001602 | 0.80 | MAPT (0.53) | MAPTTP53CETPHSD17B10THRB | |
| SCHEMBL9514445 | 0.79 | MAPT (0.65) | MAPTTP53HSD17B10KDM4EALDH1A1 | |
| SCHEMBL13254495 | 0.77 | KDM4E (0.59) | MAPTTP53UTRNHTR2BHSD17B10 | |
| SCHEMBL5638115 | 0.77 | MAPT (0.70) | MAPTTP53UTRNHTR2BHSD17B10 | |
| SCHEMBL18309416 | 0.76 | MAPT (0.50) | MAPTTP53CETPUTRNHTR2B | |
| SCHEMBL12608957 | 0.76 | MAOA (0.67) | MAPTTP53UTRNHTR2BHSD17B10 | |
| SCHEMBL1675515 | 0.76 | MAPT (0.65) | MAPTTP53HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1732161-A | 1,3-diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARM INC (US) | 2006-02-08 | — | — | CN | claimed |
| EP-1534693-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004022523-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | claimed |
| CN-1732161-A | 1,3-diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARM INC (US) | 2006-02-08 | — | — | CN | disclosed |