Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175564 | 0.87 | LMNA (0.39) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173352 | 0.80 | CYP3A4 (0.35) | CCR6ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6175237 | 0.80 | CCR6 (0.43) | CCR6ARPDE2A | |
| SCHEMBL6171968 | 0.76 | CYP3A4 (0.36) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6174909 | 0.75 | TRPV4 (0.37) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173842 | 0.74 | PRKDC (0.36) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6177653 | 0.71 | TRPV4 (0.37) | CCR6ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL2941010 | 0.70 | CYP3A4 (0.36) | CCR6ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL2942599 | 0.70 | IGF1R (0.45) | — | |
| SCHEMBL6175704 | 0.69 | POLB (0.36) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |