Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 10/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170630 | 0.84 | IGF1R (0.39) | ALDH1A1IGF1RSLC22A12GAACYP3A4 | |
| SCHEMBL6175120 | 0.70 | IGF1R (0.45) | ALDH1A1IGF1RSLC22A12GAACYP3A4 | |
| SCHEMBL6171982 | 0.69 | IGF1R (0.41) | IGF1RGAACYP2C9 | |
| SCHEMBL6173832 | 0.68 | IGF1R (0.40) | ALDH1A1IGF1RSLC22A12 | |
| SCHEMBL6174769 | 0.68 | IGF1R (0.39) | ALDH1A1IGF1R | |
| SCHEMBL6178331 | 0.67 | CYP3A4 (0.41) | ALDH1A1IGF1RSLC22A12GAACYP3A4 | |
| SCHEMBL6171813 | 0.67 | IGF1R (0.41) | ALDH1A1IGF1RGAACYP3A4CYP2C9 | |
| SCHEMBL6172761 | 0.66 | IGF1R (0.42) | ALDH1A1IGF1R | |
| SCHEMBL6173549 | 0.66 | IGF1R (0.43) | ALDH1A1IGF1RGAACYP3A4CYP2C9 | |
| SCHEMBL6172569 | 0.66 | IGF1R (0.36) | ALDH1A1P2RX3IGF1RGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |