Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175864 | 0.84 | ALDH1A1 (0.37) | IGF1RSLC22A12GAACYP2C9ALDH1A1 | |
| SCHEMBL6171982 | 0.81 | IGF1R (0.41) | IGF1RLMNAGAACYP2C9 | |
| SCHEMBL6175510 | 0.75 | IGF1R (0.45) | IGF1RSLC22A12 | |
| SCHEMBL6175120 | 0.73 | IGF1R (0.45) | IGF1RSLC22A12GAACYP2C9ALDH1A1 | |
| SCHEMBL6175512 | 0.72 | IGF1R (0.37) | IGF1RSLC22A12LMNA | |
| SCHEMBL6173832 | 0.71 | IGF1R (0.40) | IGF1RSLC22A12LMNAKMT2AALDH1A1 | |
| SCHEMBL6173988 | 0.71 | LMNA (0.42) | IGF1RLMNAGAACYP2C9MEN1 | |
| SCHEMBL6178331 | 0.71 | CYP3A4 (0.41) | IGF1RSLC22A12LMNAGAACYP2C9 | |
| SCHEMBL6176971 | 0.70 | IGF1R (0.40) | IGF1RLMNAGAACYP2C9MEN1 | |
| SCHEMBL2940050 | 0.69 | IGF1R (0.67) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |