Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173832 | 0.89 | IGF1R (0.40) | ALDH1A1SLC22A12IGF1RLMNA | |
| SCHEMBL6174506 | 0.89 | CYP3A4 (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173005 | 0.85 | CYP3A4 (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173549 | 0.82 | IGF1R (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174921 | 0.82 | IGF1R (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174310 | 0.82 | IGF1R (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6171727 | 0.81 | HSD11B1 (0.36) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173913 | 0.81 | IGF1R (0.43) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6173174 | 0.81 | IGF1R (0.44) | ALDH1A1IGF1R | |
| SCHEMBL6174587 | 0.81 | MAPT (0.37) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |