Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174388 | 0.90 | MAPK7 (0.39) | GPR139CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6175295 | 0.89 | POLB (0.35) | HCRTR1HCRTR2CYP3A4GAACYP2C9 | |
| SCHEMBL6173272 | 0.88 | GPR139 (0.34) | GPR139CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6172276 | 0.86 | IGF1R (0.41) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175751 | 0.85 | AR (0.41) | GPR139CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173665 | 0.85 | MAPT (0.36) | GPR139GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL6177961 | 0.83 | MAPK7 (0.39) | GPR139CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL3729343 | 0.83 | MAPK7 (0.42) | GPR139CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173690 | 0.82 | CYP3A4 (0.41) | HCRTR1HCRTR2CYP3A4GAACYP2C9 | |
| SCHEMBL6171217 | 0.80 | GPR139 (0.43) | GPR139HCRTR1HCRTR2CYP3A4P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |