Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174388 | 0.90 | MAPK7 (0.39) | POLBL3MBTL1ARTRPV4PDE2A | |
| SCHEMBL6175936 | 0.89 | GPR139 (0.40) | POLBL3MBTL1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL6173272 | 0.88 | GPR139 (0.34) | POLBL3MBTL1ARTRPV4PDE2A | |
| SCHEMBL6177887 | 0.86 | PIK3CG (0.37) | POLBL3MBTL1NPBWR1MCHR1OPRM1 | |
| SCHEMBL6175751 | 0.85 | AR (0.41) | POLBL3MBTL1ARALDH1A1CYP3A4 | |
| SCHEMBL6171829 | 0.85 | IGF1R (0.42) | ARMAPTCYP2C9 | |
| SCHEMBL6173665 | 0.85 | MAPT (0.36) | POLBL3MBTL1TRPV4PDE2AALDH1A1 | |
| SCHEMBL6176261 | 0.82 | DDR1 (0.38) | POLBL3MBTL1NPBWR1MCHR1AR | |
| SCHEMBL6172582 | 0.80 | ALDH1A1 (0.36) | POLBL3MBTL1NPBWR1MCHR1LIPE | |
| SCHEMBL6174465 | 0.79 | MAPK7 (0.39) | POLBL3MBTL1NPBWR1MCHR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |