Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | CBLB | Q13191 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174358 | 0.94 | NPC1 (0.39) | LMNAGAACYP2C9NPC1RAB9A | |
| SCHEMBL6175145 | 0.93 | ALDH1A1 (0.40) | LMNAGAACYP2C9NPC1RAB9A | |
| SCHEMBL6175398 | 0.92 | GRM5 (0.43) | LMNAGAACYP2C9NPC1RAB9A | |
| SCHEMBL6753615 | 0.92 | GAA (0.46) | LMNAGAACYP2C9NPC1RAB9A | |
| SCHEMBL6175127 | 0.88 | CYP2C9 (0.38) | LMNAGAACYP2C9NPC1RAB9A | |
| SCHEMBL6175972 | 0.86 | IGF1R (0.44) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL6173058 | 0.85 | IGF1R (0.36) | LMNAGAACYP2C9MEN1KMT2A | |
| SCHEMBL6175073 | 0.85 | IGF1R (0.38) | LMNACYP2C9RAB9AMEN1KMT2A | |
| SCHEMBL6175269 | 0.84 | MAPT (0.40) | GAACYP2C9KMT2ATHRBMAPT | |
| SCHEMBL6174924 | 0.84 | EPHX2 (0.39) | LMNACYP2C9NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |