Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178301 | 0.90 | EPHX2 (0.41) | MAPK7EPHX2 | |
| SCHEMBL6173461 | 0.88 | IGF1R (0.39) | MAPTPOLBTP53CFTRNPSR1 | |
| SCHEMBL6173425 | 0.88 | LMNA (0.38) | MAPTPOLBSMN1; SMN2TP53CFTR | |
| SCHEMBL4849527 | 0.85 | PDE2A (0.37) | POLBSCN9AALDH1A1GAACYP3A4 | |
| SCHEMBL6171821 | 0.85 | PDE2A (0.39) | POLBTP53ALDH1A1GAACYP3A4 | |
| SCHEMBL6173023 | 0.83 | IGF1R (0.38) | POLBSCN9AALDH1A1GAACYP3A4 | |
| SCHEMBL6173118 | 0.81 | KCNA5 (0.41) | KCNA5CCKARMGLLMAPTNPC1 | |
| SCHEMBL6173122 | 0.81 | KCNA5 (0.41) | KCNA5CCKARMGLLMAPTNPC1 | |
| SCHEMBL6174541 | 0.81 | SLC5A1 (0.40) | MAPTPOLBGAACYP3A4CYP2C9 | |
| SCHEMBL6172376 | 0.79 | ALDH1A1 (0.37) | POLBALDH1A1GAACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |