Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 6/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176573 | 0.90 | KCNA5 (0.41) | EPHX2MAPK7 | |
| SCHEMBL6173405 | 0.87 | IGF1R (0.40) | — | |
| SCHEMBL6175941 | 0.87 | PTGS2 (0.39) | — | |
| SCHEMBL6173023 | 0.85 | IGF1R (0.38) | EPHX2ABL1GPR139 | |
| SCHEMBL4849527 | 0.85 | PDE2A (0.37) | EPHX2ABL1GPR139 | |
| SCHEMBL6172577 | 0.85 | ABL1 (0.46) | ABL1BCRGPR139 | |
| SCHEMBL6174541 | 0.82 | SLC5A1 (0.40) | GPR139 | |
| SCHEMBL6171821 | 0.82 | PDE2A (0.39) | EPHX2GPR139LIPE | |
| SCHEMBL6172198 | 0.81 | EPHX2 (0.43) | EPHX2ABL1BCRMAPK7PKM | |
| SCHEMBL6172200 | 0.81 | EPHX2 (0.40) | EPHX2ABL1BCRGPR139MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |