Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23566407 | 0.85 | HTT (0.63) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL14635929 | 0.83 | HTT (0.60) | HTTRAB9ANPC1TRPV1ATM | |
| SCHEMBL6589523 | 0.78 | BCHE (0.59) | MAPTHPGD | |
| SCHEMBL10809575 | 0.76 | HTT (0.45) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL7532358 | 0.76 | KMT2A (0.68) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL30648563 | 0.74 | RAB9A (0.88) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL10813641 | 0.74 | CACNA1H (0.45) | HTTRAB9ANPC1KDRMAPT | |
| SCHEMBL14439750 | 0.73 | NPC1 (0.61) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL3820618 | 0.73 | HTT (0.66) | HTTRAB9ANPC1ATMMEN1 | |
| SCHEMBL23566394 | 0.73 | USP2 (0.68) | HTTRAB9ANPC1ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |