Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.51 |
| ▸ | MDM4 | O15151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528445 | 0.83 | KCNK3 (0.77) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL27838167 | 0.81 | SLC6A4 (0.48) | BCHEMAPTPOLBKDM4E | |
| SCHEMBL8654405 | 0.78 | KCNK3 (0.57) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL7511265 | 0.78 | HDAC3 (0.61) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL21711305 | 0.78 | NR1H4 (0.75) | KCNK3KCNK9HPGDPOLBNR1H4 | |
| SCHEMBL8902669 | 0.78 | KCNK3 (0.57) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL6971074 | 0.78 | NR1H4 (0.57) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL6176906 | 0.78 | HTT (0.54) | MAPTHPGD | |
| SCHEMBL1691425 | 0.77 | NR1H4 (0.61) | KCNK3KCNK9MAPTHPGDPOLB | |
| SCHEMBL6963256 | 0.77 | NR1H4 (0.60) | KCNK3KCNK9MAPTHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472216-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | Axys Pharmaceuticals (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066579-A2 | NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS (US) | 2003-08-14 | — | — | WO | disclosed |