SCHEMBL617705

SCHEMBL617705

NC(CC(O)c1cccc(O)c1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KYNU Q16719 1/20 1.00
HIF1A Q16665 4/20 0.54
LMNA P02545 3/20 0.54
KDM4E B2RXH2 2/20 0.54
GRIA2 P42262 1/20 0.50
ADRB1 P08588 2/20 0.49
ADRA1A P35348 2/20 0.49
GRM2 Q14416 2/20 0.49
GRM3 Q14832 2/20 0.49
ADRB2 P07550 1/20 0.49
HTR1A P08908 1/20 0.49
ADRA2A P08913 1/20 0.49
ADRB3 P13945 1/20 0.49
TSHR P16473 1/20 0.49
ADRA2B P18089 1/20 0.49
ADRA2C P18825 1/20 0.49
NFKB1 P19838 1/20 0.49
DRD1 P21728 1/20 0.49
HTR7 P34969 1/20 0.49
ADRA1B P35368 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alanine SCHEMBL28328677 0.94 KYNU (0.89) KYNUHIF1ALMNAKDM4EGRIA2
SCHEMBL9064883 0.83 KYNU (0.70) KYNULMNAGRM2GRM3
SCHEMBL3581364 0.83 KYNU (0.70) KYNULMNAGRM2GRM3
SCHEMBL9065063 0.83 KYNU (0.70) KYNULMNAGRM2GRM3
SCHEMBL9065025 0.83 KYNU (0.70) KYNULMNAGRM2GRM3
SCHEMBL25712023 0.81 KYNU (0.68) KYNUHIF1ALMNAKDM4EADRB1
SCHEMBL27665730 0.80 KYNU (0.67) KYNUHIF1ALMNAKDM4EGRIA2
SCHEMBL27643924 0.80 KYNU (0.67) KYNUHIF1ALMNAKDM4EGRIA2
SCHEMBL27278720 0.79 KYNU (0.65) KYNUHIF1ALMNAKDM4EADRB1
SCHEMBL27643934 0.77 KYNU (0.62) KYNUHIF1ALMNAKDM4EGRIA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12280047-B2 Treatment of aneurysms GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2025-04-22 US claimed
US-20230143415-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2023-05-11 US claimed
US-11376248-B2 Treatment of aneurysms GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2022-07-05 US claimed
US-20200138810-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2020-05-07 US claimed
WO-2019006384-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2019-01-03 WO claimed
US-12280047-B2 Treatment of aneurysms GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2025-04-22 US disclosed
US-11896615-B2 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators JUNO THERAPEUTICS, INC. (US) 2024-02-13 US disclosed
EP-4190335-A1 IMMUNOTHERAPY METHODS AND COMPOSITIONS INVOLVING TRYPTOPHAN METABOLIC PATHWAY MODULATORS Juno Therapeutics, Inc. (US) 2023-06-07 EP disclosed
US-20230143415-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2023-05-11 US disclosed
US-20230143415-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2023-05-11 US disclosed
EP-3525803-B1 IMMUNOTHERAPY METHODS AND COMPOSITIONS INVOLVING TRYPTOPHAN METABOLIC PATHWAY MODULATORS JUNO THERAPEUTICS INC (US) 2022-12-07 EP disclosed
US-11376248-B2 Treatment of aneurysms GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2022-07-05 US disclosed
US-11376248-B2 Treatment of aneurysms GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2022-07-05 US disclosed
US-20200138810-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2020-05-07 US disclosed
US-20200138810-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2020-05-07 US disclosed
WO-2019006384-A1 TREATMENT OF ANEURYSMS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2019-01-03 WO disclosed
EP-2536713-A1 (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS Pfizer Inc. (US) 2012-12-26 EP disclosed
US-20120041026-A1 (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS PFIZER INC. 2012-02-16 US disclosed
WO-2011101774-A1 (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS PFIZER INC. (US) 2011-08-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143415-A1 TREATMENT OF ANEURYSMS KYNU, HAAO, HCAR2 KYNU 1/4885HIF1A 1861/4885LMNA 600/4885
US-11896615-B2 Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators KYNU, IDO1, IDO2 KYNU 1/4885HIF1A 1559/4885LMNA 4001/4885
US-12280047-B2 Treatment of aneurysms KYNU, HAAO, HCAR2 KYNU 1/4885HIF1A 1861/4885LMNA 600/4885
US-20120041026-A1 (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS HTR4, HTR1A, HTR3B KYNU 289/4885HIF1A 3764/4885LMNA 4257/4885
US-11376248-B2 Treatment of aneurysms KYNU, HAAO, HCAR2 KYNU 1/4885HIF1A 1861/4885LMNA 600/4885
US-20200138810-A1 TREATMENT OF ANEURYSMS KYNU, HAAO, HCAR2 KYNU 1/4885HIF1A 1861/4885LMNA 600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.