Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.49 |
| ▸ | CTSK | P43235 | 7/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178833 | 0.86 | AAK1 (0.47) | AAK1CTSKATMCTSLCTSB | |
| SCHEMBL6178836 | 0.86 | AAK1 (0.47) | AAK1CTSKATMCTSLCTSB | |
| SCHEMBL6177368 | 0.82 | AAK1 (0.50) | AAK1CTSKATMCTSSCTSL | |
| SCHEMBL6178018 | 0.80 | ITGB1 (0.49) | AAK1CTSKATMCTSSCTSL | |
| SCHEMBL7164311 | 0.72 | CTSK (0.56) | AAK1CTSKATMCTSSCTSL | |
| SCHEMBL7371431 | 0.72 | CTSK (0.56) | AAK1CTSKATMCTSSCTSL | |
| SCHEMBL3295285 | 0.72 | PSMB1 (0.67) | CTSKATMCTSSCTSLCTSB | |
| SCHEMBL7345183 | 0.72 | CTSK (0.56) | AAK1CTSKCTSSCTSLCTSB | |
| SCHEMBL7163358 | 0.72 | CTSK (0.56) | AAK1CTSKCTSSCTSLCTSB | |
| SCHEMBL3327332 | 0.72 | PSMB1 (0.67) | CTSKATMCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091943-B1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PROD INC (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6355662-B1 | PEPTIDE AND NONPEPTIDES AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS | PFIZER INC | 2002-03-12 | — | — | US | disclosed |
| US-6306887-B1 | AROMATIC UREAS, CARBAMATES AND TRIAMINONITRILES AND HETEROCYCLIC COMPOUNDS | PFIZER INC | 2001-10-23 | — | — | US | disclosed |
| EP-1091943-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | Pfizer Products Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000477-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2000-01-06 | — | — | WO | disclosed |