Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171082 | 0.92 | ALDH1A1 (0.35) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6173613 | 0.89 | KIF11 (0.37) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6172647 | 0.87 | CYP3A4 (0.35) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6173546 | 0.87 | KMT2A (0.36) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6173489 | 0.86 | DPP4 (0.36) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6173750 | 0.86 | KMT2A (0.39) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6176692 | 0.86 | KMT2A (0.36) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6172103 | 0.86 | RXFP1 (0.42) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6171994 | 0.86 | ALDH1A1 (0.37) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 | |
| SCHEMBL6176027 | 0.86 | HRH4 (0.33) | CYP2C9CYP3A4GAACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |