Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173489 | 0.93 | DPP4 (0.36) | TACR1SLC6A9ALDH1A1CYP3A4GAA | |
| SCHEMBL6175091 | 0.91 | SLC6A9 (0.34) | TACR1SLC6A9ALDH1A1CYP3A4GAA | |
| SCHEMBL6172665 | 0.91 | SLC6A9 (0.38) | SLC6A9ALDH1A1TP53MDM2HTT | |
| SCHEMBL6175872 | 0.86 | EPHX2 (0.40) | HRH4ALDH1A1TP53MDM2CYP3A4 | |
| SCHEMBL6175204 | 0.86 | IGF1R (0.38) | HRH4TACR1ALDH1A1TP53MDM2 | |
| SCHEMBL6177902 | 0.86 | CYP2C9 (0.35) | ALDH1A1TP53CYP3A4GAACYP2C9 | |
| SCHEMBL6171082 | 0.83 | ALDH1A1 (0.35) | ALDH1A1TP53CYP3A4GAACYP2C9 | |
| SCHEMBL6172647 | 0.82 | CYP3A4 (0.35) | ALDH1A1TP53CYP3A4GAACYP2C9 | |
| SCHEMBL6173750 | 0.81 | KMT2A (0.39) | ALDH1A1TP53CYP3A4GAACYP2C9 | |
| SCHEMBL6176692 | 0.81 | KMT2A (0.36) | ALDH1A1TP53CYP3A4GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |