SCHEMBL6177988

SCHEMBL6177988

Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(N)CN2C(=O)OCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.41
TSHR P16473 2/20 0.38
MAPT P10636 2/20 0.38
CYP3A4 P08684 2/20 0.38
MCHR1 Q99705 2/20 0.37
NPSR1 Q6W5P4 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HPGD P15428 1/20 0.36
ADORA1 P30542 1/20 0.35
TP53 P04637 1/20 0.35
GFER P55789 1/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176470 0.85 TSHR (0.42) TSHRMAPTCYP3A4NPC1RAB9A
SCHEMBL7950707 0.83 PDE4B (0.38) ADORA3TSHRMAPTCYP3A4NPSR1
SCHEMBL6176995 0.83 TSHR (0.40) TSHRMAPTCYP3A4NPC1RAB9A
SCHEMBL7961449 0.82 HTT (0.43) TSHRMAPTCYP3A4MAPK1SMN1; SMN2
SCHEMBL7964984 0.81 TSHR (0.39) TSHRMAPTCYP3A4NPC1RAB9A
SCHEMBL6177133 0.81 TSHR (0.41) TSHRMAPTCYP3A4NPC1RAB9A
SCHEMBL7959036 0.80 TSHR (0.38) TSHRMAPTCYP3A4NPSR1NPC1
SCHEMBL6180213 0.80 TSHR (0.38) TSHRMAPTCYP3A4NPC1RAB9A
SCHEMBL6178904 0.80 CCKBR (0.49) TSHRMAPTCYP3A4
SCHEMBL6176322 0.79 TSHR (0.43) TSHRMAPTCYP3A4MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed