SCHEMBL6180213

SCHEMBL6180213

CCC(C)(C)C(=O)N1CC(N)C(=O)N(CC(=O)c2ccccc2C)c2cc(C)ccc21

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
CYP3A4 P08684 3/20 0.37
MAPT P10636 1/20 0.37
RIPK1 Q13546 4/20 0.37
LMNA P02545 1/20 0.35
CYP2C19 P33261 2/20 0.34
ALDH1A1 P00352 2/20 0.34
THRB P10828 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CCKAR P32238 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176995 0.92 TSHR (0.40) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL6176470 0.87 TSHR (0.42) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL6177133 0.86 TSHR (0.41) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL6178660 0.83 CCKBR (0.38) TSHRCYP3A4MAPTLMNACCKAR
SCHEMBL6178279 0.83 CYP3A4 (0.37) TSHRCYP3A4MAPTCYP2C19ALDH1A1
SCHEMBL7964984 0.83 TSHR (0.39) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL7959036 0.82 TSHR (0.38) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL7961449 0.80 HTT (0.43) TSHRCYP3A4MAPTLMNAALDH1A1
SCHEMBL6177988 0.80 ADORA3 (0.41) TSHRCYP3A4MAPTLMNACYP2C19
SCHEMBL6176322 0.80 TSHR (0.43) TSHRCYP3A4MAPTLMNACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed