Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179845 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAAS1PR1GABRPGABRD | |
| SCHEMBL811649 | 0.77 | CA12 (0.56) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29800427 | 0.77 | CA12 (0.56) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11630902 | 0.76 | ALDH1A1 (0.60) | ALDH1A1GAANPC1RAB9AMEN1 | |
| SCHEMBL28779574 | 0.76 | MKNK1 (0.46) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6178588 | 0.76 | MRGPRX4 (0.46) | ALDH1A1GAANPC1RAB9AMEN1 | |
| SCHEMBL2215985 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1P2RY12NPC1RAB9AMEN1 | |
| SCHEMBL2218769 | 0.75 | CYP1A2 (0.41) | ALDH1A1GAAGABRPGABRDGABRA1 | |
| SCHEMBL1751109 | 0.74 | P4HTM (0.57) | ALDH1A1GAANPC1RAB9AMEN1 | |
| SCHEMBL5964500 | 0.73 | OXTR (0.48) | ALDH1A1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |