Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683489 | 0.81 | TGFBR1 (0.59) | TGFBR1MAPK14 | |
| SCHEMBL15638339 | 0.80 | TGFBR1 (0.81) | TGFBR1MTORMAPK14 | |
| SCHEMBL18005423 | 0.74 | TGFBR1 (1.00) | TGFBR1MTORMAPK14 | |
| SCHEMBL6761391 | 0.74 | TGFBR1 (0.62) | TGFBR1MTORMAPK14 | |
| SCHEMBL29832164 | 0.72 | TGFBR1 (0.64) | TGFBR1MTORMAPK14 | |
| SCHEMBL6757465 | 0.72 | TGFBR1 (0.74) | TGFBR1MTORMAPK14 | |
| SCHEMBL4035268 | 0.72 | TGFBR1 (0.60) | TGFBR1MTORMAPK14 | |
| SCHEMBL4032888 | 0.72 | TGFBR1 (0.63) | TGFBR1MTORMAPK14 | |
| SCHEMBL4032785 | 0.72 | TGFBR1 (0.62) | TGFBR1MTORMAPK14 | |
| SCHEMBL4032537 | 0.72 | TGFBR1 (0.58) | TGFBR1MTORMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-A1 | NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026863-A1 | NOVEL OXAZOLE AND THIAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |