Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760981 | 0.86 | TGFBR1 (0.58) | TGFBR1MAPK14MTOR | |
| SCHEMBL6759936 | 0.86 | TGFBR1 (0.58) | TGFBR1MAPK14MTOR | |
| SCHEMBL4865043 | 0.79 | TGFBR1 (0.59) | TGFBR1MAPK14MTOR | |
| SCHEMBL4878226 | 0.79 | TGFBR1 (0.59) | TGFBR1MAPK14MTOR | |
| SCHEMBL14524733 | 0.78 | TGFBR1 (0.57) | TGFBR1MAPK14MTOR | |
| SCHEMBL14576531 | 0.77 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL4868431 | 0.77 | TGFBR1 (0.57) | TGFBR1MAPK14MTOR | |
| SCHEMBL30203968 | 0.77 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL4857758 | 0.77 | TGFBR1 (0.56) | TGFBR1MAPK14MTOR | |
| SCHEMBL21277970 | 0.76 | TGFBR1 (0.70) | TGFBR1MAPK14MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | claimed |
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | disclosed |
| US-20030166633-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166633-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 431/4885MAPK14 3277/4885MTOR 3903/4885 |
| US-20040220230-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 485/4885MAPK14 3471/4885MTOR 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.