Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175019 | 0.92 | DPP4 (0.37) | TACR1IGF1RSCN7AKCNH2SCN9A | |
| SCHEMBL6173425 | 0.90 | LMNA (0.38) | IGF1RSLC6A9SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6175494 | 0.89 | IGF1R (0.35) | TACR1IGF1RSCN7AKCNH2SCN9A | |
| SCHEMBL6173405 | 0.87 | IGF1R (0.40) | TACR1IGF1RSMN1; SMN2 | |
| SCHEMBL6178301 | 0.87 | EPHX2 (0.41) | — | |
| SCHEMBL6172914 | 0.86 | IGF1R (0.38) | PTGS2IGF1RSMN1; SMN2ARLMNA | |
| SCHEMBL6173852 | 0.82 | IGF1R (0.37) | IGF1RAR | |
| SCHEMBL6175091 | 0.82 | SLC6A9 (0.34) | PTGS2TACR1SLC6A9SMN1; SMN2LMNA | |
| SCHEMBL6172497 | 0.81 | IGF1R (0.37) | PTGS2IGF1RSMN1; SMN2ARLMNA | |
| SCHEMBL6201343 | 0.80 | PTGS2 (0.40) | PTGS2IGF1RSMN1; SMN2ARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |