Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 13/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916138 | 0.83 | ALK (0.39) | PIN1MAPT | |
| SCHEMBL6176285 | 0.81 | IGF1R (0.48) | PIN1IGF1R | |
| SCHEMBL18181774 | 0.76 | PIN1 (0.63) | PIN1GSK3BIGF1RMAPK1MAPT | |
| SCHEMBL3811561 | 0.76 | PIN1 (0.67) | PIN1GSK3BIGF1RMAPK1MAPT | |
| SCHEMBL3976795 | 0.76 | PIN1 (1.00) | PIN1GSK3BMAPK1MAPTL3MBTL1 | |
| SCHEMBL3814860 | 0.75 | PIN1 (0.62) | PIN1GSK3BIGF1RMAPK1MAPT | |
| SCHEMBL1037559 | 0.75 | PIN1 (0.65) | PIN1GSK3BL3MBTL1 | |
| SCHEMBL1204172 | 0.75 | PIN1 (0.62) | PIN1GSK3BIGF1RMAPK1 | |
| Hydrochloric Acid SCHEMBL6178818 | 0.75 | PTK2 (0.67) | GSK3BIGF1RPRKCQMAPK1 | |
| SCHEMBL21846996 | 0.74 | PIN1 (0.59) | PIN1MAPK1MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-A2 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074244-A2 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |