Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916138 | 0.87 | ALK (0.39) | MAPK8ALKMAPK9MAPK10PIN1 | |
| SCHEMBL25056307 | 0.85 | MEN1 (0.52) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL17544600 | 0.83 | IGF1R (0.51) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL30088390 | 0.83 | IGF1R (0.51) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL6178375 | 0.81 | PIN1 (0.60) | IGF1RPIN1 | |
| SCHEMBL30833628 | 0.80 | IGF1R (0.46) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL30833796 | 0.80 | IGF1R (0.46) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL17544687 | 0.75 | IGF1R (0.55) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL24260666 | 0.75 | IGF1R (0.55) | IGF1RMEN1KMT2AMAPK8CDK19 | |
| SCHEMBL30833802 | 0.75 | IGF1R (0.55) | IGF1RMEN1KMT2AMAPK8CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597251-A2 | PYRIMIDINE COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004074244-A2 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |