Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176285 | 0.87 | IGF1R (0.48) | ALKMAPK8CDK2MAPK9MAPK10 | |
| SCHEMBL6178375 | 0.83 | PIN1 (0.60) | MAPTPIN1 | |
| SCHEMBL2061884 | 0.82 | BPTF (0.44) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL2060756 | 0.80 | LRRK2 (0.43) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL30833643 | 0.79 | ALK (0.43) | ALKMAPK8CDK9MAPK9MAPK10 | |
| SCHEMBL29904714 | 0.79 | ALK (0.48) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL30833627 | 0.79 | BCL6 (0.39) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL26906809 | 0.79 | ALK (0.48) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL18812831 | 0.78 | CCNA2 (0.41) | ALKULK1MAPK8CDK9CCNA2 | |
| SCHEMBL2062564 | 0.78 | IGF1R (0.54) | ALKULK1CDK9CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |