Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21722884 | 0.90 | GAA (0.66) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL29764514 | 0.85 | MEN1 (0.86) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL6061686 | 0.85 | MEN1 (0.86) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL5889409 | 0.82 | STS (0.60) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL4193616 | 0.81 | OPRM1 (0.70) | MEN1KMT2AOPRM1 | |
| SCHEMBL6061687 | 0.81 | MEN1 (0.78) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL28694741 | 0.81 | MEN1 (0.73) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL17113510 | 0.79 | PKM (0.46) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL9260456 | 0.79 | MEN1 (0.69) | MEN1KMT2AKDM4EGAACHRM5 | |
| SCHEMBL9260459 | 0.79 | MEN1 (0.69) | MEN1KMT2AKDM4EGAACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440071-B1 | IMIDAZOPYRIDINE COMPOUNDS AS 5-HT 4? RECEPTOR MODULATORS | PFIZER (US) | 2005-10-26 | — | — | EP | disclosed |
| US-6624162-B2 | 5-HT4 receptor binding activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, Functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans. | PFIZER INC. | 2003-09-23 | — | — | US | disclosed |