Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175665 | 0.85 | PARP1 (0.51) | LMNAHTTCDK9CCNT1CDC7 | |
| SCHEMBL29574629 | 0.85 | PARP1 (0.51) | LMNAHTTCDK9CCNT1CDC7 | |
| SCHEMBL6173618 | 0.82 | CTSA (0.43) | LMNASYKCDC7MKNK1MKNK2 | |
| SCHEMBL25306127 | 0.81 | SCN9A (0.47) | SYKMKNK1MKNK2PARP1 | |
| SCHEMBL25306800 | 0.81 | L3MBTL1 (0.53) | LMNAHTT | |
| SCHEMBL15324278 | 0.80 | MAPK11 (0.53) | LMNAHTTAURKARPS6KB1PARP1 | |
| SCHEMBL29706670 | 0.80 | LMNA (0.52) | LMNAHTTSLC9A1CDK9CCNT1 | |
| SCHEMBL30658173 | 0.80 | MAPK11 (0.53) | LMNAHTTAURKARPS6KB1PARP1 | |
| SCHEMBL25307436 | 0.78 | HTR5A (0.47) | LMNAHTTDHODHCDK9CCNT1 | |
| SCHEMBL30292714 | 0.75 | GPBAR1 (0.49) | SLC9A1CDK9CCNT1CDC7MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |