Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363135 | 0.85 | HCAR3 (0.78) | HCAR3FGFR1NPC1RAB9AALDH1A1 | |
| SCHEMBL6177681 | 0.85 | HCAR3 (0.54) | HCAR3NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6176464 | 0.85 | HCAR3 (0.54) | HCAR3NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6175805 | 0.79 | ALDH1A1 (0.48) | HCAR3ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL6176252 | 0.78 | HCAR3 (0.44) | HCAR3NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6175852 | 0.75 | NPSR1 (0.46) | HCAR3NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6281552 | 0.75 | FGFR1 (0.52) | HCAR3FGFR1NPC1RAB9AALDH1A1 | |
| SCHEMBL6179506 | 0.74 | MEN1 (0.58) | FGFR1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6112848 | 0.74 | ALDH1A1 (0.65) | HCAR3FGFR1NPC1RAB9AALDH1A1 | |
| SCHEMBL6112712 | 0.74 | NPC1 (0.62) | HCAR3FGFR1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |