Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177681 | 1.00 | HCAR3 (0.54) | HCAR3RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL7721164 | 0.87 | HCAR3 (0.72) | HCAR3RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL6178549 | 0.85 | HCAR3 (0.58) | HCAR3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6175805 | 0.83 | ALDH1A1 (0.48) | HCAR3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6277706 | 0.77 | RIPK1 (0.49) | HCAR3RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL6175661 | 0.77 | RIPK1 (0.49) | HCAR3RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL8360112 | 0.76 | NAMPT (0.61) | HCAR3RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL9597592 | 0.76 | RIPK1 (0.48) | RIPK1RIPK3ALDH1A1HPGDMEN1 | |
| SCHEMBL6176252 | 0.75 | HCAR3 (0.44) | HCAR3ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30483201 | 0.74 | HCAR3 (0.46) | HCAR3RIPK1RIPK3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |