Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.55 |
| ▸ | NOS1 | P29475 | 2/20 | 0.55 |
| ▸ | NOS2 | P35228 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093094 | 1.00 | NOS3 (0.55) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL6535740 | 1.00 | NOS3 (0.55) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL890468 | 0.96 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL890472 | 0.96 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL22091990 | 0.87 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL22091993 | 0.87 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL31688563 | 0.84 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL17434420 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL9423322 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL8892097 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705050-B2 | Amides, useful in the inhibition of IL-8-induced chemotaxis of neutrophils | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2010-04-27 | — | — | US | claimed |
| EP-1255726-B1 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-11-11 | — | — | EP | claimed |
| CN-100513386-C | Amides for inhibiting interleukin 8-induced chemotaxis of neutrophils | DOMP S P A (IT) | 2009-07-15 | — | — | CN | claimed |
| US-20080221200-A1 | Combination of Organic Compounds | ALLISON MALCOLM | 2008-09-11 | — | — | US | claimed |
| EP-1940388-A2 | DPP IV INHIBTOR FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND GRAFT REJECTION | Novartis AG (CH) | 2008-07-09 | — | — | EP | claimed |
| WO-2007041368-A2 | DPP IV INHIBITOR FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND GRAFT REJECTION | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | claimed |
| CN-1479715-A | Amides for inhibiting interleukin 8-induced chemotaxis of neutrophils | ��ķ�ɷ�����˾ | 2004-03-03 | — | — | CN | claimed |
| EP-1086124-B1 | NOVEL CYCLOSPORINS | CHEM AG C (CH) | 2003-11-19 | — | — | EP | claimed |
| US-6583265-B1 | Compound for use in the prevention of viral and bacterial infections | C-CHEM AG (CH) | 2003-06-24 | — | — | US | claimed |
| EP-1255726-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.P.A. (IT) | 2002-11-13 | — | — | EP | claimed |
| WO-2001058852-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8-INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.p.A. (IT) | 2001-08-16 | — | — | WO | claimed |
| EP-1086124-A1 | NOVEL CYCLOSPORINS | C-Chem AG (CH) | 2001-03-28 | — | — | EP | claimed |
| WO-1999065933-A1 | NOVEL CYCLOSPORINS | C-CHEM AG (CH) | 1999-12-23 | — | — | WO | claimed |
| EP-0539319-B1 | Pharmaceutical cyclosporin composition | NOVARTIS AG (CH) | 1999-12-08 | — | — | EP | claimed |
| EP-0414632-B1 | Cyclosporin derivatives | SANDOZ LTD (CH) | 1996-10-23 | — | — | EP | claimed |
| US-20250250565-A1 | OLIGONUCLEOTIDES CONJUGATES COMPRISING 7'-5'-ALPHA-ANOMERIC-BICYCLIC SUGAR NUCLEOSIDES | ALPHA ANOMERIC SAS (FR) | 2025-08-07 | — | — | US | disclosed |
| US-20250171500-A1 | CONFORMATIONALLY STABILIZED RSV PRE-FUSION F PROTEINS | CALDER BIOSCIENCES INC (US) | 2025-05-29 | — | — | US | disclosed |
| EP-0539319-B1 | Pharmaceutical cyclosporin composition | NOVARTIS AG (CH) | 1999-12-08 | — | — | EP | disclosed |
| EP-0953630-A1 | Transesterification products of corn oil and glycerol and their use in pharmaceutical compositions | Novartis AG (CH) | 1999-11-03 | — | — | EP | disclosed |
| WO-1999010374-A1 | CYCLOSPORIN A CONJUGATES AND USES THEREFOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221200-A1 | Combination of Organic Compounds | DPP4, DPP3, DPP7 | NOS3 414/4885NOS1 773/4885NOS2 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.