Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.55 |
| ▸ | NOS1 | P29475 | 2/20 | 0.55 |
| ▸ | NOS2 | P35228 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617875 | 1.00 | NOS3 (0.55) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL6535740 | 1.00 | NOS3 (0.55) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL890468 | 0.96 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL890472 | 0.96 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL22091990 | 0.87 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL22091993 | 0.87 | NOS3 (0.51) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL31688563 | 0.84 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL17434420 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL9423322 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 | |
| SCHEMBL8892097 | 0.83 | NOS3 (0.53) | NOS3NOS1NOS2PTGS1SLC7A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101272780-A | DPP IV inhibitor for use in the treatment of autoimmune diseases and graft rejection | NOVARTIS AG (CH) | 2008-09-24 | — | — | CN | claimed |
| CN-1205220-C | Novel cyclosporins | CHEM AG C (CH) | 2005-06-08 | — | — | CN | claimed |
| CN-1305493-A | Novel cyclosporins | CHEM AG C (CH) | 2001-07-25 | — | — | CN | claimed |
| EP-0580690-B2 | IMPROVEMENTS IN PHARMACEUTICAL COMPOSITIONS | NOVARTIS AG (CH) | 2000-09-13 | — | — | EP | claimed |
| US-11260027-B2 | Donor organ pre-treatment formulation | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2022-03-01 | — | — | US | disclosed |
| CN-110996985-A | Composition for preventing and treating acute kidney injury | AKI医疗有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-101272780-A | DPP IV inhibitor for use in the treatment of autoimmune diseases and graft rejection | NOVARTIS AG (CH) | 2008-09-24 | — | — | CN | disclosed |
| CN-1205220-C | Novel cyclosporins | CHEM AG C (CH) | 2005-06-08 | — | — | CN | disclosed |
| CN-1305493-A | Novel cyclosporins | CHEM AG C (CH) | 2001-07-25 | — | — | CN | disclosed |