Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 3/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.49 |
| ▸ | ITGAV | P06756 | 4/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177284 | 1.00 | GABBR2 (0.56) | GABBR2GABBR1ESR1ESR2MIF | |
| SCHEMBL6177276 | 1.00 | GABBR2 (0.56) | GABBR2GABBR1ESR1ESR2MIF | |
| SCHEMBL6553384 | 0.89 | GABBR2 (0.63) | GABBR2GABBR1MIFITGB3ITGAV | |
| SCHEMBL6553378 | 0.89 | GABBR2 (0.63) | GABBR2GABBR1MIFITGB3ITGAV | |
| SCHEMBL28335512 | 0.87 | GABBR2 (0.61) | GABBR2GABBR1MIFITGB3ITGAV | |
| SCHEMBL27291057 | 0.87 | GABBR2 (0.61) | GABBR2GABBR1MIFITGB3ITGAV | |
| SCHEMBL6180314 | 0.85 | ESR1 (0.51) | GABBR2GABBR1ESR1ESR2MIF | |
| SCHEMBL27582759 | 0.85 | ESR1 (0.51) | ESR1ESR2MIFSLC7A5FNTA | |
| SCHEMBL6181144 | 0.85 | ESR1 (0.56) | GABBR2GABBR1ESR1ESR2SLC7A5 | |
| SCHEMBL6177258 | 0.85 | GABBR2 (0.54) | GABBR2GABBR1MIFITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061921-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-03-30 | — | — | EP | disclosed |
| US-20020147334-A1 | Vitronectin Receptor Antagonists | SMITHKLINE BEECHAM CORPORATION | 2002-10-10 | — | — | US | disclosed |
| CN-1299282-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2001-06-13 | — | — | CN | disclosed |
| EP-1061921-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045927-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147334-A1 | Vitronectin Receptor Antagonists | ADGRF1, FN1, CALCR | GABBR2 1280/4885GABBR1 1420/4885ESR1 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.