Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.48 |
| ▸ | CTSS | P25774 | 9/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 6/20 | 0.48 |
| ▸ | CTSL | P07711 | 10/20 | 0.46 |
| ▸ | CTSB | P07858 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516782 | 1.00 | CTSK (0.48) | CTSKCTSSPORCNCTSLCTSB | |
| SCHEMBL5516415 | 0.86 | CTSK (0.61) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5516794 | 0.86 | CTSK (0.61) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5518307 | 0.86 | CTSK (0.61) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5514720 | 0.86 | CTSK (0.61) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5509590 | 0.82 | CTSK (0.62) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5509585 | 0.82 | CTSK (0.62) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5513803 | 0.82 | CTSK (0.59) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5518599 | 0.82 | PORCN (0.46) | CTSKCTSSPORCNCTSLCTSB | |
| SCHEMBL5513770 | 0.81 | CTSK (0.55) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | claimed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | claimed |
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | disclosed |